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Outline

Our research team is developing advanced laser processing techniques which realize low environmental load, high quality, high efficiency fabrication of materials. In particular, by using femtosecond lasers, novel material processing techniques including 3D fabrication, surface nanostructuring, novel nanomaterial synthesis, and tailored beam processing are developed, which are applied to fabricate highly functional micro/nanodevices. As one of examples, our team has developed a technique that can fabricate 3D micro/nanofluidic chips using CYTOP as substrates by combining two-photon polymerization and molding process. CYTOP is an amorphous fluoropolymer with excellent transmittance over a wide range of wavelengths and the almost same refractive index as water. By taking advantage of these properties, we successfully demonstrated super-resolution live imaging of the behavior of cancer cells migrating in microchannels. The CYTOP biochips produced by the developed technique can be used for various biological studies and are expected to provide new knowledge.

Fields

Engineering, Materials Sciences, Interdisciplinary science and engineering, Multidisciplinary

Keywords

Femtosecond laser, Laser processing, Micro/nanofabrication, 3D fabrication, Biochip

Subjects

1. Development of laser-based 3D micro and nanoprocessing and application for fabrication of micro and nanodevices
2. Development of high quality, high efficiency, high resolution processing based on beam shaping techniques
3. Nanomaterials synthesis and surface nanostructuring by ultrafast lasers
4. Elucidation of laser and matter interactions

Selected Publications

1. Zhang, J., Obata, K., Ozasa, K., Uzawa, T., Ito, Y., Sugioka, K.: “Rapid manufacturing of glass-based digital nucleic acid amplification chips by ultrafast Bessel pulses”, Small Sci. 4, 2300166 (2024).
2. Kawabata, S., Bai, S., Obata, K., Miyaji, G., and Sugioka, K.: “Two-dimensional laser-induced periodic surface structures formed on crystalline silicon by GHz burst mode femtosecond laser pulses” , Int. J. Extreme Manuf. 5, 015004 (2023).
3. Bai, S., Serien, D., Ma, Y., Obata, K., and Sugioka, K.: “Attomolar sensing based on liquid-interface assisted surface enhanced Raman scattering in microfluidic chip by femtosecond laser processing”, ACS Appl. Mater. Interfaces 12, 42328-42338 (2020).
4. Bai, S., Serien, D., Hu, A., and Sugioka, K.: “Three-dimensional microfluidic SERS chips fabricated by all-femtosecond-laser-processing for real-time sensing of toxic substances” , Adv. Funct. Mater. 28, 1706262 (2018).
5. Wu, D., Xu, J., Niu, L., Wu, S., Midorikawa, K., and Sugioka, K.: “In-channel integration of designable microoptical devices using flat scaffold-supported femtosecond-laser microfabrication for coupling-free optofluidic cell counting” , Light Sci. Appl. 4, e228 (2014).

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